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Article

Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2010

Lee Shin Yup, Kim Min Jung, Jin Guang, Yoo Seung Soo, Park Ji Young, Choi Jin Eun, Jeon Hyo Sung, Cho Sukki, Lee Eung Bae, Cha Seung Ick, Park Tae-In, Kim Chang Ho, Jung Tae Hoon, Park Jae Yong

Abstract excerpt

INTRODUCTION: Epidermal growth factor receptor (EGFR) signaling pathway plays a crucial role in the development and progression of lung cancer. We searched for mutations of EGFR pathway genes in non-small cell lung cancers (NSCLCs) and analyzed their relationship with clinicopathologic features. METHODS: Mutations of EGFR, ERBB2, ERBB3, ERBB4, KRAS, NRAS, BRAF, PTEN, PIK3CA, LKB1, and AKT1 genes were determined...

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Source

Identifiers

PMID: 20881644
DOI: 10.1097/JTO.0b013e3181f0beca

Genes

EGFR
PTEN
BRAF
ERBB2
KRAS
AKT1
ERBB3
ERBB4
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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