Article
KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.
Dementia and geriatric cognitive disorders - 1 Jan 2010
Hayashi Noriyuki, Kazui Hiroaki, Kamino Kouzin, Tokunaga Hiromasa, Takaya Masahiko, Yokokoji Mikiko, Kimura Ryo, Kito Yumiko, Wada Tamiki, Nomura Keiko, Sugiyama Hiromichi, Yamamoto Daisuke, Yoshida Tetsuhiko, Currais Antonio, Soriano Salvador, Hamasaki Toshimitsu, Yamamoto Mitsuko, Yasuda Yuka, Hashimoto Ryota, Tanimukai Hitoshi, Tagami Shinji, Okochi Masayasu, Tanaka Toshihisa, Kudo Takashi, Morihara Takashi, Takeda Masatoshi
Abstract excerpt
BACKGROUND/AIMS: A single-nucleotide polymorphism (SNP) in the KIBRA gene, rs17070145, was reported to be significantly associated with episodic memory in cognitively normal cohorts. This observation has expanded genetic studies on KIBRA to Alzheimer's disease (AD). Importantly, the association between KIBRA and episodic memory in AD has never been addressed. In this study, we investigated whether the KIBRA...
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