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Article

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.

Cancer research - 15 Jan 2011

Dijkgraaf Gerrit J P, Alicke Bruno, Weinmann Lasse, Januario Thomas, West Kristina, Modrusan Zora, Burdick Dan, Goldsmith Richard, Robarge Kirk, Sutherlin Dan, Scales Suzie J, Gould Stephen E, Yauch Robert L, de Sauvage Frederic J

Abstract excerpt

Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC-0449 initially regressed tumors, but this individual ultimately relapsed with a D473H resistance mutation in Smoothened (SMO), the molecular...

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Source

Identifiers

PMID: 21123452
DOI: 10.1158/0008-5472.CAN-10-2876

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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