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Article

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

20 Jul 2011

Abstract excerpt

Acquired resistance to targeted therapies threatens the value of these otherwise very promising agents. The recent description of resistance to the Hedgehog pathway inhibitor vismodegib (GDC-0449) in a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand potential mechanisms of drug resistance. Elucidating these mechanisms will play a significant role in informing...

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PMID: 21771911
DOI: 10.1158/0008-5472.can-11-0923

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