Article
Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog.
Immunology - 1 Jan 2011
Pinheiro Dammy, Singh Yogesh, Grant Charlotte R, Appleton Richard C, Sacchini Flavio, Walker Kate R L, Chadbourne Alden H, Palmer Charlotte A, Armitage-Chan Elizabeth, Thompson Ian, Williamson Lina, Cunningham Fiona, Garden Oliver A
Abstract excerpt
Relatively little is known about regulatory T (Treg) cells and their functional responses in dogs. We have used the cross-reactive anti-mouse/rat Foxp3 antibody clone FJK-16s to identify a population of canine CD4(+) FOXP3(high) T cells in both the peripheral blood (PB) and popliteal lymph node (LN). FOXP3(+) cells in both PB and LN yielded positive staining with the newly developed anti-murine/human Helios...
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