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Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase‐1 mutant mouse in vivo: evidence for increased persistent inward currents

27 Sept 2010

Abstract excerpt

AIM: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a preferential loss of motor neurones. Previous publications using in vitro neonatal preparations suggest an increased excitability of motor neurones in various superoxide dismutase-1 (SOD1) mutant mice models of ALS which may contribute to excitotoxicity of the motor neurones. METHODS: Using intracellular...

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PMID: 20874803
DOI: 10.1111/j.1748-1716.2010.02188.x

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