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Article

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis.

eLife - 14 Oct 2014

Leroy Félix, Lamotte d'Incamps Boris, Imhoff-Manuel Rebecca D, Zytnicki Daniel

Abstract excerpt

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in adulthood. In contrast, the small motoneurons that innervate the slow-contracting fibers (S-type motoneurons) are resistant and do not degenerate. Intrinsic hyperexcitability of F-type motoneurons during early postnatal development has long been...

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PMID: 25313866
DOI: 10.7554/eLife.04046
PMCID: PMC4227046

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