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Article

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.

The Journal of physiology - 1 May 2011

Quinlan K A, Schuster J E, Fu R, Siddique T, Heckman C J

Abstract excerpt

Spinal motoneurons are highly vulnerable in amyotrophic lateral sclerosis (ALS).Previous research using a standard animal model, the mutant superoxide dismutase-1 (SOD1)mouse, has revealed deficits in many cellular properties throughout its lifespan. The electrical properties underlying motoneuron excitability are some of the earliest to change; starting at 1 week postnatal, persistent inward currents (PICs)...

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Identifiers

PMID: 21486770
DOI: 10.1113/jphysiol.2010.200659
PMCID: PMC3098701

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SOD1

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