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Article

Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome.

Human molecular genetics - 15 Dec 2010

Nistala Harikiran, Lee-Arteaga Sui, Carta Luca, Cook Jason R, Smaldone Silvia, Siciliano Gabriella, Rifkin Aaron N, Dietz Harry C, Rifkin Daniel B, Ramirez Francesco

Abstract excerpt

Reduced bone mineral density (osteopenia) is a poorly characterized manifestation of pediatric and adult patients afflicted with Marfan syndrome (MFS), a multisystem disorder caused by structural or quantitative defects in fibrillin-1 that perturb tissue integrity and TGFβ bioavailability. Here we report that mice with progressively severe MFS (Fbn1(mgR/mgR) mice) develop osteopenia associated with normal...

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Identifiers

PMID: 20871099
DOI: 10.1093/hmg/ddq409
PMCID: PMC2989889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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