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Article

Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Cook Jason R, Clayton Nicholas P, Carta Luca, Galatioto Josephine, Chiu Emily, Smaldone Silvia, Nelson Carol A, Cheng Seng H, Wentworth Bruce M, Ramirez Francesco

Abstract excerpt

OBJECTIVE: Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGFβ neutralization or AT1r antagonism. However, subsequent investigations have called...

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Identifiers

PMID: 25614286
DOI: 10.1161/ATVBAHA.114.305150
PMCID: PMC4376614

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