Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

The Journal of biological chemistry - 29 Oct 2010

Nistala Harikiran, Lee-Arteaga Sui, Smaldone Silvia, Siciliano Gabriella, Ramirez Francesco

Abstract excerpt

Mutations in fibrillin-1 or fibrillin-2, the major structural components of extracellular microfibrils, cause pleiotropic manifestations in Marfan syndrome and congenital contractural arachnodactyly, respectively. We recently found that fibrillin-1 and fibrillin-2 control bone formation by regula...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Coculture Techniques
Share to Fibrillin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrillins

Share to Microfibrils

Share to Osteoblasts

Share to Osteoclasts

Share to RANK Ligand

Source

Open in PubMed Open full text

Identifiers

PMID: 20729550
DOI: 10.1074/jbc.M110.125328
PMCID: PMC2962511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20729550-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.PMID 20729550Read ↗

Fibrillin microfibrils in bone physiology.Semantic proximity Read ↗

Fibrillin‐rich microfibrils: Structural determinants of morphogenetic and homeostatic eventsSemantic proximity Read ↗

Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGFβ Activity Within the Marrow NicheSemantic proximity Read ↗

Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome.Semantic proximity Read ↗

Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanismSemantic proximity Read ↗

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?Semantic proximity Read ↗

Fibrillin assemblies: extracellular determinants of tissue formation and fibrosisSemantic proximity Read ↗

Regulation of limb patterning by extracellular microfibrils.Semantic proximity Read ↗

Exogenous activation of BMP-2 signaling overcomes TGFβ-mediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cells.Semantic proximity Read ↗

Biogenesis and function of fibrillin assemblies.Semantic proximity Read ↗

Microenvironmental Regulation by Fibrillin-1Semantic proximity Read ↗

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.