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Genetic polymorphism in ornithine decarboxylase and risk of breast cancer.

Familial cancer - 1 Jan 2009

Brown Iain, Halliday Susan, Greig Heather, Heys Steven D, Wallace Heather M, Schofield Andrew C

Abstract excerpt

Ornithine decarboxylase (ODC), the first enzyme in the biosynthesis of polyamines, has increased activity in breast cancer tissue compared with benign and normal tissues. The ODC gene contains a single nucleotide polymorphism in which a guanine is substituted for an adenine. This study investigated whether the ODC +316 G > A polymorphism (rs2302615) was associated with the risk of developing breast cancer. A...

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PMID: 19225907
DOI: 10.1007/s10689-009-9237-9

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