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Article

Genetic diversity and functional effect of common polymorphisms in genes involved in the first heterodimeric complex of the Nucleotide Excision Repair pathway.

DNA repair - 1 Feb 2020

Hamdi Yosr, Jerbi Manel, Romdhane Lilia, Ben Rekaya Mariem, El Benna Houda, Chouchane Lotfi, Boubaker Mohamed Samir, Abdelhak Sonia, Yacoub-Youssef Houda

Abstract excerpt

Nucleotide excision repair is a multistep process that recognizes and eliminates a spectrum of DNA damages. Five proteins, namely XPC, RAD23, Centrin 2, DDB1 and DDB2 act as a heterodimeric complex at the early steps of the NER pathway and play a crucial role in the removal of DNA lesions. Several exonic mutations on genes coding for these proteins have been identified as associated with Xeroderma-pigmentosum...

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PMID: 31865061
DOI: 10.1016/j.dnarep.2019.102770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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