Article
Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk.
Breast cancer research and treatment - 1 May 2010
Dünnebier Thomas, Bermejo Justo Lorenzo, Haas Susanne, Fischer Hans-Peter, Pierl Christiane B, Justenhoven Christina, Brauch Hiltrud, Baisch Christian, Gilbert Michael, Harth Volker, Spickenheuer Anne, Rabstein Sylvia, Pesch Beate, Brüning Thomas, Ko Yon-Dschun, Hamann Ute
Abstract excerpt
SUMOylation consists in the covalent conjugation of small ubiquitin-related modifiers to target proteins. SUMOylation participates in processes that are tightly linked to tumorigenesis, and genetic variability in the SUMO-conjugating system may influence the development of breast cancer. We recently reported that variation in the UBC9 gene encoding the SUMO-conjugating enzyme may affect the grade of breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.