Article
Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade.
International journal of cancer - 1 Aug 2009
Dünnebier Thomas, Bermejo Justo Lorenzo, Haas Susanne, Fischer Hans-Peter, Pierl Christiane B, Justenhoven Christina, Brauch Hiltrud, Baisch Christian, Gilbert Michael, Harth Volker, Spickenheuer Anne, Rabstein Sylvia, Pesch Beate, Brüning Thomas, Ko Yon-Dschun, Hamann Ute
Abstract excerpt
UBC9 encodes a protein that conjugates small ubiquitin-related modifier (SUMO) to target proteins resulting in a change of their localization, activity or stability. Genetic variability may affect expression and activity of UBC9 and may have an impact on breast tumor progression. We investigated associations between UBC9 genotypes and histopathological parameters in 1,021 breast cancer cases of the GENICA...
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