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Article

Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion.

Molecular biology of the cell - 15 Nov 2010

Shibukawa Yukinao, Yamazaki Natsuko, Kumasawa Keiichi, Daimon Etsuko, Tajiri Michiko, Okada Yuka, Ikawa Masahito, Wada Yoshinao

Abstract excerpt

Cell-cell fusion is an intriguing differentiation process, essential for placental development and maturation. A proteomic approach identified a cytoplasmic protein, calponin 3 (CNN3), related to the fusion of BeWo choriocarcinoma cells. CNN3 was expressed in cytotrophoblasts in human placenta. CNN3 gene knockdown promoted actin cytoskeletal rearrangement and syncytium formation in BeWo cells, suggesting CNN3 to...

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Source

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Identifiers

PMID: 20861310
DOI: 10.1091/mbc.E10-03-0261
PMCID: PMC2982094

Genes

CNN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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