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Article

Annexin-A5 organized in 2D-network at the plasmalemma eases human trophoblast fusion

8 Feb 2017

Abstract excerpt

Only a limited number of human cells can fuse to form a multinucleated syncytium. Cell fusion occurs as part of the differentiation of some cell types, including myotubes in muscle and osteoclasts in remodeling bone. In the differentiation of the human placenta, mononuclear cytotrophoblasts aggregate and fuse to form endocrinologically active, non-proliferative, multinucleated syncytia. These syncytia allow the...

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PMID: 28176826
DOI: 10.1038/srep42173

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