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Trophoblast Cell Fusion and Differentiation Are Mediated by Both the Protein Kinase C and A Pathways

13 Nov 2013

Abstract excerpt

The syncytiotrophoblast of the human placenta is an epithelial barrier that interacts with maternal blood and is a key for the transfer of nutrients and other solutes to the developing fetus. The syncytiotrophoblast is a true syncytium and fusion of progenitor cytotrophoblasts is the cardinal event leading to the formation of this layer. BeWo cells are often used as a surrogate for cytotrophoblasts, since they...

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PMID: 24236208
DOI: 10.1371/journal.pone.0081003

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