Article

Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

2021-12-12

Abstract excerpt

TMEM16F, a Ca 2+ -activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization. How TMEM16F is activated during cell fusion is unclear. Here, we used trophoblasts as a model for cell fusion and demonstrated that Ca 2+ influx through Ca 2+ permeable transient receptor potential vanilloid channel TRPV4 is critical for...

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Literature Corpus work: b19c1337-9693-5771-b2e3-e95e1d23ba25
DOI: 10.1101/2021.12.11.472241

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