Article
A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex.
Journal of virology - 15 Sept 2020
Mishra Nitesh, Sharma Shaifali, Dobhal Ayushman, Kumar Sanjeev, Chawla Himanshi, Singh Ravinder, Das Bimal Kumar, Kabra Sushil Kumar, Lodha Rakesh, Luthra Kalpana
Abstract excerpt
The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the sole target of broadly neutralizing antibodies (bnAbs). Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to shield neutralizing epitopes on Env to sustain survival and infectivity within the host. The identification of...
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