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Article

An estimate of amyotrophic lateral sclerosis heritability using twin data.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2010

Al-Chalabi A, Fang F, Hanby M F, Leigh P N, Shaw C E, Ye W, Rijsdijk F

Abstract excerpt

BACKGROUND: Causative gene mutations have been identified in about 2% of those with amyotrophic lateral sclerosis (ALS), often, but not always, when there is a strong family history. There is an assumption that there is a genetic component to all ALS, but genome-wide association studies have yet to produce a robustly replicated result. A definitive estimate of ALS heritability is therefore required to determine...

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Identifiers

PMID: 20861059
DOI: 10.1136/jnnp.2010.207464
PMCID: PMC2988617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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