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Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

22 Jul 2019

Abstract excerpt

IMPORTANCE: Heritability describes the proportion of variance in the risk of developing a condition that is explained by genetic factors. Although amyotrophic lateral sclerosis (ALS) is known to have a complex genetic origin, disease heritability remains unclear. OBJECTIVES: To determine the extent of ALS heritability and assess the association of sex with disease transmission. DESIGN, SETTING, AND PARTICIPANTS:...

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PMID: 31329211
DOI: 10.1001/jamaneurol.2019.2044

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