The Heritability of Amyotrophic Lateral Sclerosis in a Clinically Ascertained United States Research Registry

Abstract excerpt

BACKGROUND: The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another affected individual. However, twin studies suggest that all ALS has a substantial genetic basis. Herein,...

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