Article
VKORC1 polymorphisms in Amerindian populations of Brazil.
Pharmacogenomics - 1 Nov 2008
Perini Jamila A, Petzl-Erler Maria Luiza, Tsuneto Luiza Tamie, Suarez-Kurtz Guilherme
Abstract excerpt
Noncoding polymorphisms in the VKORC1 gene associate with variation of interindividual dosing requirements of warfarin and other coumarin anticoagulants. The frequency of VKORC1 polymorphisms displays distinct interpopulation differences. Here, we report the distribution of the VKORC1 3673G>A, 5808T>G, 6853G>C and 9041G>A SNPs in three endogamous Amerindian (Native American) populations, namely, Guarani-Kaiowá,...
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