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Article

Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer.

Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2010

Chen Meng, Hildebrandt Michelle A T, Clague Jessica, Kamat Ashish M, Picornell Antoni, Chang Joshua, Zhang Xiaofan, Izzo Julie, Yang Hushan, Lin Jie, Gu Jian, Chanock Stephen, Kogevinas Manolis, Rothman Nathaniel, Silverman Debra T, Garcia-Closas Montserrat, Grossman H Barton, Dinney Colin P, Malats Núria, Wu Xifeng

Abstract excerpt

Sonic hedgehog (Shh) pathway genetic variations may affect bladder cancer risk and clinical outcomes. Therefore, we genotyped 177 single-nucleotide polymorphisms (SNP) in 11 Shh pathway genes in a study including 803 bladder cancer cases and 803 controls. We assessed SNP associations with cancer risk and clinical outcomes in 419 cases of non-muscle-invasive bladder cancer (NMIBC) and 318 cases of muscle-invasive...

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Source

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Identifiers

PMID: 20858759
DOI: 10.1158/1940-6207.CAPR-10-0035
PMCID: PMC2955764

Genes

GLI2
SHH
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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