Article
Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer.
BMC cancer - 1 Sept 2016
Roperch Jean-Pierre, Grandchamp Bernard, Desgrandchamps François, Mongiat-Artus Pierre, Ravery Vincent, Ouzaid Idir, Roupret Morgan, Phe Véronique, Ciofu Calin, Tubach Florence, Cussenot Olivier, Incitti Roberto
Abstract excerpt
BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) is a high incidence form of bladder cancer (BCa), where genetic and epigenetic alterations occur frequently. We assessed the performance of associating a FGFR3 mutation assay and a DNA methylation analysis to improve bladder cancer detection and to predict disease recurrence of NMIBC patients. METHODS: We used allele specific PCR to determine the FGFR3...
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