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Article

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data.

Genome biology - 1 Jan 2010

Yau Christopher, Mouradov Dmitri, Jorissen Robert N, Colella Stefano, Mirza Ghazala, Steers Graham, Harris Adrian, Ragoussis Jiannis, Sieber Oliver, Holmes Christopher C

Abstract excerpt

We describe a statistical method for the characterization of genomic aberrations in single nucleotide polymorphism microarray data acquired from cancer genomes. Our approach allows us to model the joint effect of polyploidy, normal DNA contamination and intra-tumour heterogeneity within a single...

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Identifiers

PMID: 20858232
DOI: 10.1186/gb-2010-11-9-r92
PMCID: PMC2965384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20858232-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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