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Article

A general model for multilocus epistatic interactions in case-control studies.

PloS one - 18 Aug 2010

Wang Zhong, Liu Tian, Lin Zhenwu, Hegarty John, Koltun Walter A, Wu Rongling

Abstract excerpt

BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases. The complexity of disease expression should arise from a complex network of epistatic interactions involving multiple genes. METHODOLOGY: We develop a general model for testing high-order epistatic interactions for a complex disease in a case-control...

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PMID: 20814428
DOI: 10.1371/journal.pone.0011384
PMCID: PMC2909900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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