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Article

S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders.

Gastroenterology - 1 Mar 2011

Feld Jordan J, Modi Apurva A, El-Diwany Ramy, Rotman Yaron, Thomas Emmanuel, Ahlenstiel Golo, Titerence Rachel, Koh Christopher, Cherepanov Vera, Heller Theo, Ghany Marc G, Park Yoon, Hoofnagle Jay H, Liang T Jake

Abstract excerpt

BACKGROUND & AIMS: Less than half of patients infected with hepatitis C virus (HCV) achieve sustained viral clearance after pegylated interferon (peginterferon) and ribavirin therapy. S-adenosyl methionine (SAMe) improves interferon signaling in cell culture. We assessed the effect of SAMe on the kinetics of the early antiviral response and interferon signaling in nonresponders to previous antiviral therapy and...

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Identifiers

PMID: 20854821
DOI: 10.1053/j.gastro.2010.09.010
PMCID: PMC3021477

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STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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