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Article

Ribavirin improves early responses to peginterferon through improved interferon signaling.

Gastroenterology - 1 Jul 2010

Feld Jordan J, Lutchman Glen A, Heller Theo, Hara Koji, Pfeiffer Julie K, Leff Richard D, Meek Claudia, Rivera Maria, Ko Myung, Koh Christopher, Rotman Yaron, Ghany Marc G, Haynes-Williams Vanessa, Neumann Avidan U, Liang T Jake, Hoofnagle Jay H

Abstract excerpt

BACKGROUND & AIMS: The therapeutic mechanisms of ribavirin for hepatitis C are unclear. Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes. We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of peginterferon therapy with and without ribavirin. METHODS: Fifty patients with chronic hepatitis C virus (HCV) infection genotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20303352
DOI: 10.1053/j.gastro.2010.03.037
PMCID: PMC2902566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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