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Article

Validation of an arterial constitutive model accounting for collagen content and crosslinking.

Acta biomaterialia - 1 Feb 2016

Tian Lian, Wang Zhijie, Liu Yuming, Eickhoff Jens C, Eliceiri Kevin W, Chesler Naomi C

Abstract excerpt

During the progression of pulmonary hypertension (PH), proximal pulmonary arteries (PAs) increase in both thickness and stiffness. Collagen, a component of the extracellular matrix, is mainly responsible for these changes via increased collagen fiber amount (or content) and crosslinking. We sought to differentiate the effects of collagen content and cross-linking on mouse PA mechanical changes using a...

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Identifiers

PMID: 26654765
DOI: 10.1016/j.actbio.2015.11.058
PMCID: PMC4728033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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