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Article

Myh11(R247C/R247C) mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity.

Journal of biomechanics - 2 Jan 2015

Bellini Chiara, Wang Shanzhi, Milewicz Dianna M, Humphrey Jay D

Abstract excerpt

Genetic studies in patients reveal that mutations to genes that encode contractile proteins in medial smooth muscle cells can cause thoracic aortic aneurysms and dissections. Mouse models of such mutations, including Acta2(-/-) and Myh11(R247C/R247C), surprisingly do not present with any severe vascular phenotype under normal conditions. This observation raises the question whether these mutations nevertheless...

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Share to Aorta
Share to Aorta, Thoracic
Share to Aortic Aneurysm, Thoracic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertension

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Share to Myocytes, Smooth Muscle

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Source

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Identifiers

PMID: 25433566
DOI: 10.1016/j.jbiomech.2014.10.031
PMCID: PMC4283495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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