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Article

Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies.

Aging cell - 1 Dec 2010

Jacobsen Rune, Martinussen Torben, Christiansen Lene, Jeune Bernard, Andersen-Ranberg Karen, Vaupel James W, Christensen Kaare

Abstract excerpt

Studies of Nordic twins suggest an increased genetic influence on mortality with age. Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals carrying a 'frail' or 'risky' genotype in a population will approach that of noncarriers with age because of selection pressure. The ApoE ε4 allele is associated with an increased mortality risk, and its effect has been suggested to...

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Identifiers

PMID: 20849521
DOI: 10.1111/j.1474-9726.2010.00626.x
PMCID: PMC2988163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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