Article
Association of ecNOS gene polymorphisms with end stage renal diseases.
Molecular and cellular biochemistry - 1 Feb 2003
Nagase Sohji, Suzuki Hiromichi, Wang Ying, Kikuchi Shuichi, Hirayama Aki, Ueda Atsushi, Takada Kenji, Oteki Takaaki, Obara Mami, Aoyagi Kazumasa, Koyama Akio
Abstract excerpt
Nitric oxide (NO) is a very potent regulator of intrarenal hemodynamics and is thought to be an important factor in the deterioration of renal function. Several polymorphisms of the endothelial NO synthase (eNOS) gene have been reported. For instance, tandem 27-bp repeats in intron 4 of the eNOS gene are polymorphic, i.e. eNOS4a allele has 4 and eNOS4b has 5 tandem repeats, and the association between eNOS4a and...
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