Article
Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men.
Journal of hypertension - 1 Jul 2007
Dell'Omo Giulia, Penno Giuseppe, Pucci Laura, Fotino Carmen, Lucchesi Daniela, Del Prato Stefano, Pedrinelli Roberto
Abstract excerpt
BACKGROUND: The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology. That same mechanism may contribute to raise albuminuria, a correlate of endothelial dysfunction and...
Topics
- Albuminuria
- Endothelium, Vascular
- Forearm
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged
- Nitric Oxide Synthase Type III
- Polymorphism, Single Nucleotide
- Regional Blood Flow
- Skin
- Vasodilation