Article
Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men.
Journal of hypertension - 1 Jul 2007
Dell'Omo Giulia, Penno Giuseppe, Pucci Laura, Fotino Carmen, Lucchesi Daniela, Del Prato Stefano, Pedrinelli Roberto
Abstract excerpt
BACKGROUND: The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology. That same mechanism may contribute to raise albuminuria, a correlate of endothelial dysfunction and...
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