Article
eNOS haplotypes associated with gestational hypertension or preeclampsia.
Pharmacogenomics - 1 Oct 2008
Sandrim Valeria C, Palei Ana Ct, Cavalli Ricardo C, Araújo Francielle M, Ramos Ester S, Duarte Geraldo, Tanus-Santos Jose E
Abstract excerpt
AIMS: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia. We compared genotype and haplotype frequencies of three eNOS gene polymorphisms in normotensive and hypertensive pregnancies. METHODS: Genotypes and haplotypes for eNOS polymorphisms (T-786C, Glu298Asp and intron 4 b/a) were determined in 326 pregnant women (110 healthy pregnancies, 103...
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