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Article

The Wnt antagonist Dickkopf-1 increases endothelial progenitor cell angiogenic potential.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2010

Smadja David M, d'Audigier Clément, Weiswald Louis-Bastien, Badoual Cécile, Dangles-Marie Virginie, Mauge Laetitia, Evrard Solène, Laurendeau Ingrid, Lallemand François, Germain Stéphane, Grelac Françoise, Dizier Blandine, Vidaud Michel, Bièche Ivan, Gaussem Pascale

Abstract excerpt

OBJECTIVE: To determine the role of Wnt antagonist Dickkopf (DKK) 1 in human endothelial colony-forming cells (ECFCs) in view of the emerging importance of Wnt pathways in vascular biology. METHODS AND RESULTS: Endothelial progenitor cells have been proposed to be crucial in tumor neovascularization. Recombinant DKK1 has been tested in ECFC angiogenic properties in vitro. DKK1 enhanced ECFC proliferation and the...

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Source

Identifiers

PMID: 20847303
DOI: 10.1161/ATVBAHA.110.213751

Genes

DKK1
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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