Article
Dickkopf-1-promoted vasculogenic mimicry in non-small cell lung cancer is associated with EMT and development of a cancer stem-like cell phenotype.
Journal of cellular and molecular medicine - 1 Sept 2016
Yao Lingli, Zhang Danfang, Zhao Xiulan, Sun Baocun, Liu Yanrong, Gu Qiang, Zhang Yanhui, Zhao Xueming, Che Na, Zheng Yanjun, Liu Fang, Wang Yong, Meng Jie
Abstract excerpt
To characterize the contributions of Dickkopf-1 (DKK1) towards the induction of vasculogenic mimicry (VM) in non-small cell lung cancer (NSCLC), we evaluated cohorts of primary tumours, performed in vitro functional studies and generated xenograft mouse models. Vasculogenic mimicry was observed in 28 of 205 NSCLC tumours, while DKK1 was detected in 133 cases. Notably, DKK1 was positively associated with VM....
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