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Article

Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapy.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2010

Shitara Kohei, Matsuo Keitaro, Ito Seiji, Sawaki Akira, Kawai Hiroki, Yokota Tomoya, Takahari Daisuke, Shibata Takashi, Ura Takashi, Ito Hidemi, Hosono Satoyo, Kawase Takakazu, Watanabe Miki, Tajima Kazuo, Yatabe Yasushi, Tanaka Hideo, Muro Kei

Abstract excerpt

OBJECTIVE: Tumor cells that overexpress P-glycoprotein (Pgp) may be resistant to several anticancer agents due to altered pharmacokinetics and reduced intracellular concentrations of the anticancer agents. Pgp is encoded by the ATP binding cassette gene B1 (ABCB1). To our knowledge, only one previous report has evaluated the effect of ABCB1 gene polymorphisms on clinical outcomes of gastric cancer. The purpose of...

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Identifiers

PMID: 20843132

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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