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Article

Efficacy of a therapeutic vaccine using mutated β-amyloid sensitized dendritic cells in Alzheimer's mice.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Sept 2012

Luo Zhongqiu, Li Jialin, Nabar Neel R, Lin Xiaoyang, Bai Ge, Cai Jianfeng, Zhou Shu-Feng, Cao Chuanhai, Wang Jinhuan

Abstract excerpt

Despite FDA suspension of Elan's AN-1792 amyloid beta (Aβ) vaccine in phase IIb clinical trials, the implications of this study are the guiding principles for contemporary anti-Aβ immunotherapy against Alzheimer's disease (AD). AN-1792 showed promising results with regards to Aβ clearance and cognitive function improvement, but also exhibited an increased risk of Th1 mediated meningoencephalitis. As such, vaccine...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22684353
DOI: 10.1007/s11481-012-9371-2

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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