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Article

Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients.

Journal of neurochemistry - 1 Apr 2011

Zetterström Per, Andersen Peter M, Brännström Thomas, Marklund Stefan L

Abstract excerpt

Several of the superoxide dismutase-1 (SOD1) mutations linked to amyotrophic lateral sclerosis (ALS) lead to synthesis of structurally defective molecules, suggesting that any cytotoxic conformational species common for all mutations should be misfolded. SOD1 can be secreted and evidence from ALS model systems suggests that extracellular SOD1 may be involved in cytotoxicity. Three ELISAs specifically reacting...

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Source

Identifiers

PMID: 21226712
DOI: 10.1111/j.1471-4159.2011.07177.x

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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