Article
Phenotype and functional analysis of human monocytes-derived dendritic cells loaded with a carbosilane dendrimer.
Biomaterials - 1 Nov 2010
Pion Marjorie, Serramia Maria J, Diaz Laura, Bryszewska Maria, Gallart Teresa, García Felipe, Gómez Rafael, de la Mata Francisco J, Muñoz-Fernandez Maria Á
Abstract excerpt
Dendritic cells (DCs) play a major role in development of cell-mediated immunotherapy due to their unique role in linking innate and adaptive immunities. In spite of improvement in this area, strategies employing ex vivo generated DCs have shown limited efficacy in clinical trials. Dendrimers have been proposed as new carriers for drug delivery in aim to ameliorate DCs antigen loading that is a pivotal point in...
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