Article
Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy.
Journal of immunological methods - 1 Apr 2004
Waeckerle-Men Ying, Scandella Elke, Uetz-Von Allmen Edith, Ludewig Burkhard, Gillessen Silke, Merkle Hans P, Gander Bruno, Groettrup Marcus
Abstract excerpt
Dendritic cells (DC) are increasingly explored as cellular vaccines for tumor immunotherapy. In most reported DC-based cancer vaccine trials, DC have been pulsed with soluble tumor antigen-derived peptide ligands of MHC molecules. Considering that the half-life of peptide/MHC complexes on the cel...
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