Article
Response to angiotensin-converting enzyme inhibition is selectively blunted by high sodium in angiotensin-converting enzyme DD genotype: evidence for gene-environment interaction in healthy volunteers.
Journal of hypertension - 1 Dec 2010
Lely A Titia, Heerspink Hiddo J Lambers, Zuurman Mike, Visser Folkert W, Kocks Menno J A, Boomsma Frans, Navis Gerjan
Abstract excerpt
BACKGROUND: Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype relationship, we hypothesize gene-environment interaction between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.