Article
Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.
Leukemia - 1 Jun 2015
Witkowski M T, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie M D, Best S A, Tuohey L, Willson T A, Nutt S L, Busslinger M, Aifantis I, Smyth G K, Dickins R A
Abstract excerpt
Activating NOTCH1 mutations occur in ~60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory interplay between these driver genes, we have used a novel transgenic RNA interference mouse model to produce primary T-ALLs driven by reversible Ikaros knockdown. Restoring endogenous Ikaros...
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