Article
Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children.
Infection and immunity - 1 Nov 2010
Cham Gerald K K, Turner Louise, Kurtis Jonathan D, Mutabingwa Theonest, Fried Michal, Jensen Anja T R, Lavstsen Thomas, Hviid Lars, Duffy Patrick E, Theander Thor G
Abstract excerpt
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant antigen expressed on the surface of malaria-infected erythrocytes. PfEMP1 attaches to the vascular lining and allows infected erythrocytes to avoid filtration through the spleen. Each parasite genome encodes about 60 different PfEMP1 variants, each PfEMP1 comprises several domains in its extracellular region, and the PfEMP1 repertoire in...
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