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Article

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria.

PLoS genetics - 1 May 2021

Shah Zalak, Naung Myo T, Moser Kara A, Adams Matthew, Buchwald Andrea G, Dwivedi Ankit, Ouattara Amed, Seydel Karl B, Mathanga Don P, Barry Alyssa E, Serre David, Laufer Miriam K, Silva Joana C, Takala-Harrison Shannon

Abstract excerpt

Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals...

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PMID: 34033654
DOI: 10.1371/journal.pgen.1009576
PMCID: PMC8184011

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