Article
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies.
The Journal of experimental medicine - 6 Sept 2021
Michelow Ian C, Park Sangshin, Tsai Shu-Whei, Rayta Bonnie, Pasaje Charisse Flerida A, Nelson Sara, Early Angela M, Frosch Anne P, Ayodo George, Raj Dipak K, Nixon Christina E, Nixon Christian P, Pond-Tor Sunthorn, Friedman Jennifer F, Fried Michal, Duffy Patrick E, Le Roch Karine G, Niles Jacquin C, Kurtis Jonathan D
Abstract excerpt
We previously identified a Plasmodium falciparum (Pf) protein of unknown function encoded by a single-copy gene, PF3D7_1134300, as a target of antibodies in plasma of Tanzanian children in a whole-proteome differential screen. Here we characterize this protein as a blood-stage antigen that localizes to the surface membranes of both parasitized erythrocytes and merozoites, hence its designation as Pf erythrocyte...
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