Article
Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis.
Haematologica - 1 Dec 2010
Scholtysik René, Kreuz Markus, Klapper Wolfram, Burkhardt Birgit, Feller Alfred C, Hummel Michael, Loeffler Markus, Rosolowski Maciej, Schwaenen Carsten, Spang Rainer, Stein Harald, Thorns Christoph, Trümper Lorenz, Vater Inga, Wessendorf Swen, Zenz Thorsten, Siebert Reiner, Küppers Ralf
Abstract excerpt
BACKGROUND: Knowledge about the genetic lesions that occur in Burkitt's lymphoma, besides the pathognomonic IG-MYC translocations, is limited. DESIGN AND METHODS: Thirty-nine molecularly-defined Burkitt's lymphomas were analyzed with high-resolution single-nucleotide polymorphism chips for genomic imbalances and uniparental disomy. Imbalances were correlated to expression profiles and selected micro-RNA analysis....
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