Article
Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression.
British journal of haematology - 1 Nov 2011
Schiffman Joshua D, Lorimer Patrick D, Rodic Vladimir, Jahromi Mona S, Downie Jonathan M, Bayerl Michael G, Sanmann Jennifer N, Althof Pamela A, Sanger Warren G, Barnette Phillip, Perkins Sherrie L, Miles Rodney R
Abstract excerpt
The majority of paediatric Burkitt lymphoma (pBL) patients that relapse will die of disease, but markers for this high-risk subset are unknown. MYC translocations characterize pBL, but additional genetic changes may relate to prognosis and serve as potential biomarkers. We utilized a molecular inversion probe single nucleotide polymorphism assay to perform high resolution, genome-wide copy number analysis on...
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